Create an install folder (this page will use "C:\Install_Folder" as an example) that can host a "Calibre-Web" folder. Extract the "Calibre-Web" files into the install folder, rename the folder to "Calibre-Web".

Change the directory to the "Calibre-Web" folder and install the requirements by running:

cd C:\Install_Folder\Calibre-Web
python -m pip install -r requirements.txt

Start Calibre-Web via python c:\Install_Folder\Calibre-Web\cps.py

Using Windows Scheduler to auto-run application

Create batch script file (Run_Calibre_Web.bat) name it whatever you want. I put the batch file in "C:\Install_Folder", you can place it where ever you like. You should not place the batch file into the Calibre-Web folder structure, as it will be overwritten by Calibre-Web updates. Insert the below code into the batch file, change the directories to suit your needs:

"C:\Users\UserName\AppData\Local\Programs\Python\Python37-32\python.exe" "C:\Install_Folder\Calibre-Web\cps.py"

Create Schedule Task

General Tab
Make sure you select the highlighted areas

Triggers Tab

Actions Tab (I am using "C:\Install_Folder") to place the batch file

Settings Tab

With the schedule task, Calibre-Web will run on its own even with the user logged off