[[NW.js|http://tiddlywiki.com/#NW.js]] (previously known as "node-webkit") allows TiddlyWiki to be set up as a native application for Windows, Mac OS X or Linux.
MP3 audio and H264 video are not supported without special steps [[described on the NW.js wiki|https://github.com/nwjs/nw.js/wiki/Using-MP3-%26-MP4-%28H.264%29-using-the--video--%26--audio--tags.]].