diff --git a/app/src/main/java/org/schabi/newpipe/fragments/detail/VideoDetailFragment.java b/app/src/main/java/org/schabi/newpipe/fragments/detail/VideoDetailFragment.java
index 580585d4e..7078ecffb 100644
--- a/app/src/main/java/org/schabi/newpipe/fragments/detail/VideoDetailFragment.java
+++ b/app/src/main/java/org/schabi/newpipe/fragments/detail/VideoDetailFragment.java
@@ -642,19 +642,7 @@ public final class VideoDetailFragment
                         ? View.VISIBLE
                         : View.GONE
         );
-
-        if (DeviceUtils.isTv(getContext())) {
-            // remove ripple effects from detail controls
-            final int transparent = ContextCompat.getColor(requireContext(),
-                    R.color.transparent_background_color);
-            binding.detailControlsPlaylistAppend.setBackgroundColor(transparent);
-            binding.detailControlsBackground.setBackgroundColor(transparent);
-            binding.detailControlsPopup.setBackgroundColor(transparent);
-            binding.detailControlsDownload.setBackgroundColor(transparent);
-            binding.detailControlsShare.setBackgroundColor(transparent);
-            binding.detailControlsOpenInBrowser.setBackgroundColor(transparent);
-            binding.detailControlsPlayWithKodi.setBackgroundColor(transparent);
-        }
+        accommodateForTvAndDesktopMode();
     }
 
     @Override
@@ -2118,6 +2106,30 @@ public final class VideoDetailFragment
         }
     }
 
+    /**
+     * Make changes to the UI to accommodate for better usability on bigger screens such as TVs
+     * or in Android's desktop mode (DeX etc).
+     */
+    private void accommodateForTvAndDesktopMode() {
+        if (DeviceUtils.isTv(getContext())) {
+            // remove ripple effects from detail controls
+            final int transparent = ContextCompat.getColor(requireContext(),
+                    R.color.transparent_background_color);
+            binding.detailControlsPlaylistAppend.setBackgroundColor(transparent);
+            binding.detailControlsBackground.setBackgroundColor(transparent);
+            binding.detailControlsPopup.setBackgroundColor(transparent);
+            binding.detailControlsDownload.setBackgroundColor(transparent);
+            binding.detailControlsShare.setBackgroundColor(transparent);
+            binding.detailControlsOpenInBrowser.setBackgroundColor(transparent);
+            binding.detailControlsPlayWithKodi.setBackgroundColor(transparent);
+        }
+        if (DeviceUtils.isDesktopMode(getContext())) {
+            // Remove the "hover" overlay (since it is visible on all mouse events and interferes
+            // with the video content being played)
+            binding.detailThumbnailRootLayout.setForeground(null);
+        }
+    }
+
     private void checkLandscape() {
         if ((!player.isPlaying() && player.getPlayQueue() != playQueue)
                 || player.getPlayQueue() == null) {
diff --git a/app/src/main/java/org/schabi/newpipe/util/DeviceUtils.java b/app/src/main/java/org/schabi/newpipe/util/DeviceUtils.java
index 3c20dc04b..46ab6da51 100644
--- a/app/src/main/java/org/schabi/newpipe/util/DeviceUtils.java
+++ b/app/src/main/java/org/schabi/newpipe/util/DeviceUtils.java
@@ -1,14 +1,17 @@
 package org.schabi.newpipe.util;
 
+import android.annotation.SuppressLint;
 import android.app.UiModeManager;
 import android.content.Context;
 import android.content.pm.PackageManager;
 import android.content.res.Configuration;
 import android.graphics.Point;
+import android.hardware.input.InputManager;
 import android.os.BatteryManager;
 import android.os.Build;
 import android.provider.Settings;
 import android.util.TypedValue;
+import android.view.InputDevice;
 import android.view.KeyEvent;
 import android.view.WindowInsets;
 import android.view.WindowManager;
@@ -22,6 +25,10 @@ import androidx.preference.PreferenceManager;
 import org.schabi.newpipe.App;
 import org.schabi.newpipe.R;
 
+import java.lang.reflect.Method;
+
+import static android.content.Context.INPUT_SERVICE;
+
 public final class DeviceUtils {
 
     private static final String AMAZON_FEATURE_FIRE_TV = "amazon.hardware.fire_tv";
@@ -84,6 +91,78 @@ public final class DeviceUtils {
         return DeviceUtils.isTV;
     }
 
+    /**
+     * Checks if the device is in desktop or DeX mode. This function should only
+     * be invoked once on view load as it is using reflection for the DeX checks.
+     * @param context the context to use for services and config.
+     * @return true if the Android device is in desktop mode or using DeX.
+     */
+    @SuppressWarnings("JavaReflectionMemberAccess")
+    public static boolean isDesktopMode(@NonNull final Context context) {
+        // Adapted from https://stackoverflow.com/a/64615568
+        // to check for all input devices that have an active cursor
+        final InputManager im = (InputManager) context.getSystemService(INPUT_SERVICE);
+        for (final int id : im.getInputDeviceIds()) {
+            final InputDevice inputDevice = im.getInputDevice(id);
+            if (inputDevice.supportsSource(InputDevice.SOURCE_BLUETOOTH_STYLUS)
+                    || inputDevice.supportsSource(InputDevice.SOURCE_MOUSE)
+                    || inputDevice.supportsSource(InputDevice.SOURCE_STYLUS)
+                    || inputDevice.supportsSource(InputDevice.SOURCE_TOUCHPAD)
+                    || inputDevice.supportsSource(InputDevice.SOURCE_TRACKBALL)) {
+                return true;
+            }
+        }
+
+        final UiModeManager uiModeManager =
+                ContextCompat.getSystemService(context, UiModeManager.class);
+        if (uiModeManager != null
+                && uiModeManager.getCurrentModeType() == Configuration.UI_MODE_TYPE_DESK) {
+            return true;
+        }
+
+        // DeX check for standalone and multi-window mode, from:
+        // https://developer.samsung.com/samsung-dex/modify-optimizing.html
+        try {
+            final Configuration config = context.getResources().getConfiguration();
+            final Class<?> configClass = config.getClass();
+            final int semDesktopModeEnabledConst =
+                    configClass.getField("SEM_DESKTOP_MODE_ENABLED").getInt(configClass);
+            final int currentMode =
+                    configClass.getField("semDesktopModeEnabled").getInt(config);
+            if (semDesktopModeEnabledConst == currentMode) {
+                return true;
+            }
+        } catch (final NoSuchFieldException | IllegalAccessException ignored) {
+            // Device doesn't seem to support DeX
+        }
+
+        @SuppressLint("WrongConstant") final Object desktopModeManager = context
+                .getApplicationContext()
+                .getSystemService("desktopmode");
+
+        if (desktopModeManager != null) {
+            try {
+                final Method getDesktopModeStateMethod = desktopModeManager.getClass()
+                        .getDeclaredMethod("getDesktopModeState");
+                final Object desktopModeState = getDesktopModeStateMethod
+                        .invoke(desktopModeManager);
+                final Class<?> desktopModeStateClass = desktopModeState.getClass();
+                final Method getEnabledMethod = desktopModeStateClass
+                        .getDeclaredMethod("getEnabled");
+                final int enabledStatus = (int) getEnabledMethod.invoke(desktopModeState);
+                if (enabledStatus == desktopModeStateClass
+                        .getDeclaredField("ENABLED").getInt(desktopModeStateClass)) {
+                    return true;
+                }
+            } catch (final Exception ignored) {
+                // Device does not support DeX 3.0 or something went wrong when trying to determine
+                // if it supports this feature
+            }
+        }
+
+        return false;
+    }
+
     public static boolean isTablet(@NonNull final Context context) {
         final String tabletModeSetting = PreferenceManager.getDefaultSharedPreferences(context)
                 .getString(context.getString(R.string.tablet_mode_key), "");